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Talk Python To Me

A podcast on Python and related technologies


#1
Python Podcast
11+
Years Running
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Latest episode: #551 Stroll Down Startup Lane - 2026

If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk.

Upcoming episodes

Charlie Marsh
Charlie Marsh
(up next)
Astral joins OpenAI

Michael Booth
Michael Booth
(and then)
Hyper-Personal Software with Python

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"The podcast has been a wealth of information and has positively contributed to my efforts to learn Python. Frankly, the podcast is the best way I've found to augment the training videos, documentation, and books I've used to learn the language."
— Dennis M.
"This is the podcast that got me into listening to nearly only technical ones. All the episodes are fun and informative, and I can't recommend it enough for every Pythonista."
— Nikola Kantar
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— Ronak15

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One of my go-to podcasts for commutes!
Whether your just taking an interest in Python or are an experienced developer, this podcast seems to cater equally well to both types. Consistency engaging and interesting topics and really helps you stay connected to what is going on in the Python world. Thanks Michael!
— WhitePelican
Michael Kennedy has a fantastic personality for tech podcasts, I have always found his explanations light-hearted enough to be entertaining, but with enough detail that it's interesting and worth listening to in order to learn. In my experience, that's a rare combination in tech podcasts.
— Godel_unicode 39
Best thing ever for a commuting Pythonist
This podcast is a godsend. I have long commutes everyday and I always want to make the most out of my commutes. Talk Python podcast is the best product that serves my needs. I get to learn new technologies and keeping updated with the Python ecosystem every time listening to it. Great podcast! Keep it up!
— Burke Squires
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Python Bytes Podcast

Do you enjoy Talk Python To Me? We created a second podcast to be the perfect counterpart to the long-form interview format.

Python Bytes delivers Python headlines directly to your earbuds in just 15-20 minutes per week. The topical items of the Python ecosystem, condensed and ready to go.

Michael Kennedy
Michael Kennedy
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About the Show

Talk Python to Me is a weekly podcast covering a wide array of Python topics as well as many related technologies. Each episode features a casual 1-hour conversation with industry experts.

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